User:Mr. Ibrahem/Anti-thymocyte globulin

Anti-thymocyte globulin (ATG), sold under the brand name Atgam and Thymoglobulin among others, are medication used to prevent and treat acute rejection follow an organ transplant. Other uses may include myelodysplastic syndrome and aplastic anemia. It is given by injection into a vein.

Common side effects include fever, low white blood cells, low platelets, headache, nausea, serum sickness, and rash. Other side effects may include anaphylaxis and infection. Safety in pregnancy is unclear. They are polyclonal antibody against thymocytes, derived from either horses or rabbits. They are believed to work by altering the activity of T cells.

Anti-thymocyte globulin was approved for medical use in the United States in 1981 for the horse version and 1998 for the rabbit version. In the United Kingdom a 25 mg vial of the rabbit version costs the NHS about £160 as of 2021. This amount in the United States costs about US$800.