User:Mr. Ibrahem/Apremilast

Apremilast, sold under the brand name Otezla among others, is a medication used to treat plaque psoriasis, psoriatic arthritis, and Behçet's disease. It is used when other treatments are not effective. It is taken by mouth.

Common side effects include diarrhea, nausea, the common cold, and headaches. Other side effects may include depression and weight loss. Safety in pregnancy is unclear, with evidence of harm in other animals. It is an inhibitor of the enzyme phosphodiesterase 4 (PDE4) which results in a decrease in cytokins.

Apremilast was approved for medical use in the United States in 2014 and Europe in 2015. In the United Kingdom 4 weeks of treatment costs the NHS about £550 as of 2021. In the United States this amount costs about 4,100 USD.