User:Mr. Ibrahem/Aprepitant

Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. It may be used together with ondansetron and dexamethasone. It is taken by mouth.

Common side effects include tiredness, loss of appetite, diarrhea, abdominal pain, hiccups, itchiness, pneumonia, and blood pressure changes. Other severe side effects may include anaphylaxis. While use in pregnancy does not appear to be harmful, such use has not been well studied. Aprepitant belongs to the class of neurokinin-1 receptor antagonists medications. It works by blocking substance P from attaching to the NK1 receptors.

Aprepitant was approved for medical use in Europe and the United States in 2003. It is made by Merck & Co. It is on the World Health Organization's List of Essential Medicines. In the United States it about US$230 per dose. This amount in the United Kingdom cost the NHS about £16. A form that can be given by injection into a vein, known as fosaprepitant is also available.