User:Mr. Ibrahem/Atovaquone/proguanil

Atovaquone/proguanil, sold under the trade names Malarone among others, is a combination of two antimalarial medication atovaquone and proguanil. It is used to treat and prevent malaria, including chloroquine-resistant malaria. It is not recommended for severe or complicated malaria. It is taken by mouth.

Common side effects include abdominal pain, vomiting, diarrhea, cough, and itchiness. Serious side effects may include anaphylaxis, Stevens–Johnson syndrome, hallucinations, and liver problems. It is unclear if use during pregnancy or breastfeeding is safe for the baby. It is not recommended to prevent malaria in those with poor kidney function. Atovaquone works by interfering with the function of mitochondria in malaria while proguanil by blocking dihydrofolate reductase.

Atovaquone/proguanil was approved for medical use in the United States in 2000. It has been available as a generic medication since 2011. In the United Kingdom it costs £2.10 per dose as of 2019. The wholesale cost in the United States is $US 2.82 per dose as of 2019.