User:Mr. Ibrahem/Avapritinib

Avapritinib, sold under the brand name Ayvakit, is a medication used to treat systemic mastocytosis and gastrointestinal stromal tumor (GIST). In GIST it is used for cases with a platelet-derived growth factor receptor A (PDGFRA) exon 18 mutation. It is taken by mouth.

Common side effects nausea, tiredness, low red blood cells, swelling, high bilirubin, diarrhea, and forgetfulness. Other side effects may include pleural effusion and intracranial bleeding. Use in pregnancy may harm the baby. It is a tyrosine kinase inhibitor that blocks the activity of PDGFRA.

Avapritinib was approved for medical use in the United States and Europe in 2020. In the United Kingdom a month costs the NHS about £26,700 as of 2021. This amount in the United States costs about 34,200 USD.