User:Mr. Ibrahem/Aztreonam

Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, sepsis, and gonorrhoea. It is given by injection into a vein or muscle or breathed in as a mist.

Common side effects when given by injection include pain at the site of injection, vomiting, and rash. Common side effects when inhaled include wheezing, cough, and vomiting. Serious side effects include Clostridium difficile infection and allergic reactions including anaphylaxis. Those who are allergic to other β-lactam have a low rate of allergy to aztreonam. Use in pregnancy appears to be safe. It is in the monobactam family of medications. It is a manufactured version of a chemical from the bacterium Chromobacterium violaceum. Aztreonam usually results in bacterial death through blocking their ability to make a cell wall.

Aztreonam was approved for medical use in the United States in 1986. It was removed from the World Health Organization's List of Essential Medicines in 2019. It is available as a generic medication. In the UK the injectable form costs the NHS about £35 per day while the inhaled form costs about £2,200 for a course of treatment, as of 2021.