User:Mr. Ibrahem/Carbimazole

Carbimazole (CMZ) is a medication used to treat overactive thyroid, including Grave's disease. In the United Kingdom, it is the first choice antithyroid medicine. It can take a month or two before full effects. It is taken by mouth.

Side effects may include fever, rash, and joint pain. Rare side effects may include bone marrow problems resulting in low white blood cells. Other side effects may include pancreatitis. Use during pregnancy may harm the baby; though, it has been used in pregnancy due to there also being harms of high thyroid.

It is a type of thioamide, along with propylthiouracil (PTU). After absorption it is converted to the active form, methimazole. Methimazole prevents the thyroid peroxidase enzyme from adding iodine and coupling the tyrosine residues on thyroglobulin, hence reducing the production of T3 and T4.

Carbimazole came into medical use in 1952. It is on the World Health Organization's List of Essential Medicines as an alternative to methimazole. It is available as a generic medication. In the United Kingdom three month at a dose of 20 mg per day costs the NHS about £6 as of 2023.