User:Mr. Ibrahem/Carglumic acid

Carglumic acid, sold under the brand name Carbaglu among others, is a medication used to treat high ammonia due to N-acetylglutamate synthase (NAGS) deficiency, propionic acidemia (PA) or methylmalonic acidemia (MMA). It is taken by mouth.

Common side effects include vomiting, abdominal pain, fever, tonsillitis, low red blood cells, diarrhea, infections, low red blood cells, low blood sugar, pancreatitis, electrolyte abnormalities, and headache. Safety in pregnancy is unclear. It is a carbamoyl phosphate synthetase 1 (CPS 1) activator, which works by activating an enzyme that breaks down ammonia.

Carglumic acid was approved for medical use in Europe in 2003 and the United States in 2010. It is available as a generic medication. In the United Kingdom 60 tablets of 200 mg costs the NHS about £2,600 as of 2021. This amount in the United States costs about 13,400 USD. A generic version was approved in 2021 in the USA.