User:Mr. Ibrahem/Ceftazidime/avibactam

Ceftazidime/avibactam, sold under the brand name Avycaz among others, is a combination medication composed of ceftazidime, a cephalosporin antibiotic, and avibactam, a β-lactamase inhibitor. It is used to treat complicated intra abdominal infections, urinary tract infections, and pneumonia. It is only recommended when other options are not appropriate. It is given by injection into a vein.

Common side effect include nausea, fever, liver problems, headache, trouble sleeping, and pain at the site of injection. Severe side effects may include anaphylaxis, seizures, and Clostridium difficile-associated diarrhea. While use appears to be safe in pregnancy the medication has not been well studied in this group. Doses should be adjusted in those with kidney problems. Ceftazidime works by interfering with the building of the bacterial cell wall while avibactam works by preventing ceftazidime's breakdown.

The combination was approved for medical use in the United States and Europe in 2015. It is on the World Health Organization's List of Essential Medicines. In the United States a course of treatment generally costs between US$7,500 to US$15,000 as of 2016. In the United Kingdom this amount costs the NHS about £1,800 to £3,600 as of 2019.