User:Mr. Ibrahem/Clofarabine

Clofarabine, sold under the brand name Clolar and Evoltra, is a medication used to treat acute lymphoblastic leukaemia (ALL). It is used when other treatments stop working. It is given by gradual injection into a vein.

Common side effects include low white blood cells with a fever, anxiety, headache, flushing, nausea, diarrhea, itchiness, and tiredness. Other side effects may include bone marrow suppression and tumor lysis syndrome. Use during pregnancy may harm the baby. It is a antimetabolite, specifically an analogue of adenine. As such it disrupts DNA polymerase and RNA reductase preventing the making of new DNA and RNA.

Clofarabine was approved for medical use in the United States in 2004 and Europe in 2006. It is available as a generic medication. In the United Kingdom 20 mg costs the NHS about £1,325 as of 2021. In the United States this amount costs about 650 USD.