User:Mr. Ibrahem/Dantrolene

Dantrolene sodium, sold under the brand name Dantrium among others, is a medication used to treat malignant hyperthermia, neuroleptic malignant syndrome, and muscle spasticity. This may include spasticity such as due to multiple sclerosis, cerebral palsy, or stroke. Other possible uses include MDMA toxicity. It may be used by injection into a vein or by mouth.

Common side effects include sleepiness, dizziness, weakness, and diarrhea. Intravenous use may also result in inflammation at the site. Other side effects may include liver problems or palpitations. It works by blocking Ca2+ ions release by skeletal muscles and thereby preventing their contraction.

Dantrolene was first made in 1967 by Snyder. It was approved for medical use in the United States in 1974. It is available as a generic medication. Hospitals are recommended to keep at least 36 vials totaling 720 mg on hand, enough for a 70-kg person. This amount in the United Kingdom costs the NHS about £1,800 and in the United States about 3,000 USD as of 2020.