User:Mr. Ibrahem/Darunavir

Darunavir (DRV), sold under the brand name Prezista among others, is an antiretroviral medication used to treat and prevent HIV/AIDS. It is generally recommended for use with other antiretrovirals. It is often used with low doses of ritonavir or cobicistat to increase darunavir levels. It may be used for prevention after a needlestick injury or other potential exposure. It is taken by mouth once to twice a day.

Common side effects include diarrhea, nausea, abdominal pain, headache, rash and vomiting. Severe side effects include allergic reactions, liver problems, and skin rashes such as toxic epidermal necrolysis. While poorly studied in pregnancy it appears to be safe for the baby. It is of the protease inhibitor (PI) class and works by blocking HIV protease.

Darunavir was approved for medical use in the United States in 2006 and in the European Union in February 2007. It is on the World Health Organization's List of Essential Medicines. The wholesale cost in the developing world is about US$66 per month. In the United States it costs more than $200 per month. The combination darunavir/cobicistat is available as a single pill.