User:Mr. Ibrahem/Denosumab

Denosumab, sold under the brand names Prolia and Xgeva, is used to treat osteoporosis, bone cancer, and high calcium due to cancer. It is given by injection under the skin. It is used with calcium supplements and vitamin D.

Common side effects include joint and muscle pain. Other side effects may include cellulitis, low calcium, allergic reactions, and osteonecrosis of the jaw. It is a monoclonal antibody that attaches to and inhibits RANKL, which decreases osteoclasts breaking down bone.

Denosumab was approved for medical use in the United States and Europe in 2010. In the United Kingdom 60 mg cost the NHS about £180 as of 2021. In the United States this amount costs about 1,250 USD.