User:Mr. Ibrahem/Dextromethorphan/quinidine

Dextromethorphan/quinidine, sold under the brand name Nuedexta, is a combination medication used to treat pseudobulbar affect (PBA). This includes PBA that may occur in amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and dementia. It is taken by mouth.

Common side effects include diarrhea, dizziness, cough, vomiting, peripheral swelling, and urinary tract infection. Other side effects may include low platelets, QT prolongation, liver problems, and serotonin syndrome. It contains dextromethorphan, a NMDA receptor antagonist and quinidine, a CYP2D6 inhibitor. Quinidine is used to increase the activity of dextromethorphan.

The combination was approved for medical use in the United States in 2010. While it was approved in Europe in 2013; this approval was subsequently withdrawn. In the United States 60 tablets costs about 1,300 USD as of 2021.