User:Mr. Ibrahem/Dihydroergotamine

Dihydroergotamine (DHE), sold under the brand name Migranal among others, is a medication used to treat migraines, cluster headaches, and medication overuse headaches. It has a particular benefit in hard to treat migraines. It may be used as a nasal spray or by injection. Onset is within 5 to 30 minutes.

Common side effects include high blood pressure, flushing, sweating, and nausea. Other side effects may include myocardial ischemia, stroke, arrhythmia, and ergotism. Use is not recommended during pregnancy, in those with liver or kidney problems, or those with vascular disease. It is a derivative of ergotamine. It activates serotonin receptors as well as dopamine and adrenergic receptors.

Dihydroergotamine was first made in 1943 and has been in medical use since. It is available as a generic medication. In the United States it costs about 45 USD per dose by injection and 370 USD per dose in the nose as of 2021. As of the 2010s it is less commonly used than triptans.