User:Mr. Ibrahem/Doxepin

Doxepin is a medication used to treat major depressive disorder, anxiety disorders, chronic hives, and trouble sleeping. For hives it is a less preferred alternative to antihistamines. It has a mild to moderate benefit for sleeping problems. It is used as a cream for itchiness due to atopic dermatitis or lichen simplex chronicus.

Common side effects include sleepiness, dry mouth, constipation, nausea, and blurry vision. Serious side effects may include suicide in those under the age of 25, mania, and urinary retention. A withdrawal syndrome may occur if the dose is rapidly decreased. Use during pregnancy and breastfeeding is not generally recommended. Doxepin is a tricyclic antidepressant (TCA). While how it works for treating depression is unclear, it may involve increasing the levels of norepinephrine, along with blocking histamine, acetylcholine, and serotonin.

Doxepin was approved for medical use in the United States in 1969. It is available as a generic medication. A month supply in the United Kingdom costs the NHS at least £100 as of 2019. In the United States the wholesale cost of this amount is about US$23. In 2017, it was the 240th most commonly prescribed medication in the United States, with more than two million prescriptions.