User:Mr. Ibrahem/Ergotamine

Ergotamine, sold under the brand names Ergomar among others, is a medication used to treat migraines, cluster headaches, and post partum bleeding. It is not effective for tension headaches. It is taken by mouth, under the tongue, or rectally. Onset of effects is generally between 30 minutes and 2 hours.

Common side effects include nausea, abdominal pain, and tingling extremities. Other side effects may include medication overuse headaches, pulmonary fibrosis, and ergotism. Use in pregnancy or when breastfeeding may harm the baby. It is not recommended in people with vascular disease, liver, or kidney problems. It is in the ergot family of medications and acts on serotonin among other receptors.

Ergotamine was first isolated by Arthur Stoll in 1918 from ergot fungus. The fungus had been used medicinally since at least the 16th century to induce childbirth, treat bleeding after childbirth, or bring about an abortion. In the United States it is generally only used if triptans are not effective; though remains commonly used in some parts of the world. It is also available with caffeine under the brand Cafergot among others.