User:Mr. Ibrahem/Esomeprazole

Esomeprazole, sold under the brand names Nexium among others, is a medication which reduces stomach acid. It is used to treat gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. Effectiveness is similar to other proton pump inhibitors (PPIs). It is taken by mouth or injection into a vein.

Common side effects include headache, constipation, dry mouth, and abdominal pain. Serious side effects may include angioedema, Clostridium difficile infection, and pneumonia. Use in pregnancy appears to be safe, while safety during breastfeeding is unclear. Esomeprazole is the (S)-(−)-isomer of omeprazole. It works by blocking H+/K+-ATPase in the parietal cells of the stomach.

It was patented in 1993 and approved for medical use in 2000. It is available as a generic medication and sold over the counter in a number of countries. A month supply in the United Kingdom costs the NHS about £3 as of 2019. In the United States the wholesale cost of this amount is about US$10. In 2017, it was the 88th most commonly prescribed medication in the United States, with more than nine million prescriptions. It is also available without a prescription in the United States.