User:Mr. Ibrahem/Fidaxomicin

Fidaxomicin, sold under the brand name Dificid among others, is an antibiotic used to treat Clostridioides difficile diarrhea. Evidence for use in severe disease is limited and in such cases vancomycin is preferred. It is taken by mouth.

Common side effects include nausea and constipation. Other side effects may include gastrointestinal bleeding, abdominal pain, allergic reaction, and liver problems. Safety in pregnancy and breastfeeding is unclear. It is a macrocyclic which works by blocking bacterial RNA polymerase.

Fidaxomicin was approved for medical use in the United States and Europe in 2011. It was approved in Canada in 2012. In the United Kingdom a course of treatment costs the NHS about £1350 as of 2021. In the United States this amount costs about 4,150 USD. It is made from the actinomycete Dactylosporangium aurantiacum.