User:Mr. Ibrahem/Glecaprevir/pibrentasvir

Glecaprevir/pibrentasvir (G/P), sold under the brand names Mavyret and Maviret, is a fixed-dose combination medication used to treat hepatitis C. It contains glecaprevir and pibrentasvir. It works against all six types of hepatitis C. At twelve weeks following treatment between 81% and 100% of people have no evidence of hepatitis C. It is taken once a day by mouth with food.

The most common side effects are headache, diarrhea, and tiredness. In those with a history of hepatitis B reactivation may occur. It is not recommended in people with moderate to severe liver disease. Glecaprevir works by blocking the protein NS3/4A protease, while pibrentasvir works by blocking NS5A.

The combination was approved for medical use in the United States and Europe in 2017. It is on the World Health Organization's List of Essential Medicines. In the United States, a course of treatment costs about $27,600 as of 2019. This amount in the United Kingdom costs the NHS about £26,000 as of 2018.