User:Mr. Ibrahem/Glucarpidase

Glucarpidase, sold under the brand name Voraxaze, is a medication used to treat toxicity due to methotrexate (defined as > 1 micromol/L) due to impaired kidney function. It is used together with leucovorin. It is given by injection into a vein. Effects are significant within 15 minutes and last for about a week.

Common side effects include numbness, flushing, nausea, low blood pressure, and headache. Other side effects may include anaphylaxis. Safety in pregnancy is unclear. It is an enzyme that inactivates methotrexate.

Glucarpidase was approved for medical use in the United States in 2012. While it is available as an orphan medication in the United Kingdom and Europe, it is not approved as of 2021. In the United States a vial of 1,000 units costs about 35,500 USD as of 2021.