User:Mr. Ibrahem/Hereditary amyloidosis transthyretin-related

Hereditary amyloidosis transthyretin-related (hATTR) is a condition that can result in numbness of the limbs, carpal tunnel syndrome, autonomic dysfunction, and cardiomyopathy. As the disease progresses severe diarrhea, weight loss, and low blood pressure with standing may occur.

It is due to a autosomal dominant genetic mutation which is inherited from a person's parents or newly occurs during early development. Various mutations may be involved. The underlying mechanism involves build-up of the protein amyloid in body tissues. Diagnosis is based on symptoms, biopsy, and genetic testing. It is a type of amyloidosis.

Treatments may include liver transplantation in early disease. The medications patisiran, inotersen, or vutrisiran may be used for nerve problems while tafamidis may be used for heart problems. Death generally occurs around 10 years after symptom onset.

Familial amyloid polyneuropathy occurs in about 4% of African Americans and 1 in 100,000 white people. Onset of symptoms is usually in those 40 to 65 years old. It was first described by Portuguese neurologist Mário Corino da Costa Andrade, in 1952.