User:Mr. Ibrahem/Hydralazine

Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms. It has been found to be particularly useful in heart failure, together with isosorbide dinitrate, for treatment of people of African descent. It is given by mouth or by injection into a vein. Effects usually begin around 15 minutes and last up to six hours.

Common side effects include headache and fast heart rate. Rare but serious side effects include peripheral neuropathy and drug fever. It is not recommended in people with coronary artery disease or in those with rheumatic heart disease that affects the mitral valve. In overdose, a lupus-like illness can occur. In those with kidney disease a low dose is recommended. Hydralazine is in the vasodilator family of medications and works by causing the dilation of blood vessels.

Hydralazine was discovered while scientists at Ciba were looking for a treatment for malaria. It was patented in 1949. It is on the World Health Organization's List of Essential Medicines. The wholesale cost in the developing world is about US$2.78–9.11 per month. In the United States treatment costs about $50–100 per month. In 2017, it was the 105th most commonly prescribed medication in the United States, with more than seven million prescriptions.