User:Mr. Ibrahem/Imipramine

Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) used to treat depression, anxiety disorders including panic disorder, bed wetting, and postherpetic neuralgia. It is taken by mouth.

Common side effects include dry mouth, sleepiness, constipation, blurry vision, and low blood pressure with standing. Other side effects may include mania, sunburns, seizures, and suicide. Safety in pregnancy is unclear. How it works is not clear but may involve increasing levels of serotonin and norepinephrine.

Imipramine was discovered in 1951 and came into medical use in 1959. It was the first TCA to be marketed. It is available as a generic medication. In the United Kingdom 4 weeks of 25 mg costs the NHS about £7 as of 2021. This amount in the United States is about 10 USD.