User:Mr. Ibrahem/Indometacin

Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for pain and inflammation. This may include painful periods, gout, arthritis, and pericarditis. Other uses include to close a patent ductus arteriosus is a premature baby. It may be used by mouth, in the rectum, or by injection.

Common side effects include nausea, heart burn, and dizziness. Severe side effects may include cardiovascular disease, gastrointestinal bleeding, heart failure, kidney injury, and allergic reactions. Use is not recommended during the last third of pregnancy. Indometacin works by decreasing the production of prostaglandin by the enzyme cyclooxygenase.

Indometacin was patented in 1961 and approved for medical use in 1963. It is on the World Health Organization's List of Essential Medicines as an alternative to ibuprofen. It is available as a generic medication and marketed under a number of trade names. As of 2015 the cost for a typical month of medication in the United States is less than 25 USD. In the United Kingdom this amount costs the NHS less than 5 pounds as of 2020. In 2017, it was the 291st most commonly prescribed medication in the United States, with more than one million prescriptions.