User:Mr. Ibrahem/Isoniazid/rifapentine

Isoniazid/rifapentine is a combination medication used to treat tuberculosis. Specifically it is used once a week for three months for latent TB. It decreases risks of progress from infection to disease by 60 to 90%. It is taken by mouth once per week for 12 weeks.

Side effects may include liver problems, low platelets, and allergic reactions. Use is not recommended in pregnancy. There are many potential medication interactions. It is a combination of isoniazid and rifapentine. Isoniazid works in part by disrupting the formation of the bacteria's cell wall. Rifapentine is in the rifamycin family of medication and works by blocking DNA-dependent RNA polymerase.

The combination was added to the World Health Organization's List of Essential Medicines in 2021. The individual medications were previously included in 2015 and 1977. As of 2022 the individual medications costs about 73 USD per course of treatment in the developing world.