User:Mr. Ibrahem/Istradefylline

Istradefylline, sold under the brand name Nourianz, is a medication used with levodopa/carbidopa for "off" episodes in Parkinson's disease (PD). An "off" episode is a time when other medications are not working well, resulting in tremor and difficulty walking. It is taken by mouth.

Common side effects include involuntary muscle movements, constipation, hallucinations, dizziness, nausea, and trouble sleeping. Other side effects may include compulsive behavior. It is a adenosine A2A receptor antagonist.

Istradefylline was approved for medical use in the United States in 2019. In Europe it was refused approval in 2021 due to unclear evidence of benefit. It is not available in the United Kingdom. In the United States it costs about 1,500 USD per month.