User:Mr. Ibrahem/Ivacaftor

Ivacaftor, sold under the brand name Kalydeco, is a medication used to treat cystic fibrosis. Specifically it is used for cases that have specific mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It is taken by mouth.

Common side effects include headache, throat pain, runny nose, abdominal pain, diarrhea, rash, and nausea. Other side effects may include liver problems. There is no evidence of harm in pregnancy, but such use has not been well studied. It works by increasing the effectiveness of CFTR.

Ivacaftor was approved for medical use in the United States and Europe in 2012. In the United Kingdom a year of treatment costs the NHS about £196,000 as of 2021. In the United States this amount costs about 350,000 USD. It is also available in combination as lumacaftor/ivacaftor, tezacaftor/ivacaftor, and elexacaftor/tezacaftor/ivacaftor.