User:Mr. Ibrahem/Lamivudine/zidovudine

Lamivudine/zidovudine, sold under the brand name Combivir among others, is a fixed-dose combination medication used to treat HIV/AIDS. It contains two antiretroviral medications, lamivudine and zidovudine. It is used together with other antiretrovirals. It is taken by mouth twice a day.

Common side effects include headache, feeling tired, nausea, diarrhea, and fever. Severe side effects may include bone marrow suppression, muscle damage, worsening of hepatitis B if previously infected, high blood lactate and liver enlargement. It may be part of a recommended treatment during pregnancy. The medications are both of the nucleoside reverse transcriptase inhibitor (NRTI) class. They work by blocking the action of the enzyme, reverse transcriptase, that the virus requires to reproduce.

Lamivudine/zidovudine was approved for medical use in the United States in 1997 and in the European Union in 1998. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. The wholesale cost in the developing world is about US$6.90 to $29.64 per month. As of 2015 the cost for a typical month of medication in the United States more than $200.