User:Mr. Ibrahem/Linaclotide

Linaclotide, sold under the brand name Linzess and Constella, is a medication used to treat irritable bowel syndrome with constipation and chronic constipation of unknown cause. It is taken by mouth.

Common side effects include diarrhea, abdominal pain, and intestinal gas. Rarely this may lead to dehydration, low potassium, and low blood pressure with standing. It works by attaching to guanylate cyclase C receptors in the intestines which results in greater fluid release.

Linaclotide was approved for medical use in the United States and Europe in 2012. In 2017, it was the 257th most commonly prescribed medication in the United States, with more than one million prescriptions. In the United Kingdom 4 weeks of medication costs the NHS about £38 as of 2021. This amount in the United States costs about 430 USD.