User:Mr. Ibrahem/Losartan/hydrochlorothiazide

Losartan/hydrochlorothiazide, sold under the trade name Hyzaar among others, is a combination medication used to treat high blood pressure when losartan is not sufficient. It consists of losartan (an angiotensin II receptor antagonist) and hydrochlorothiazide (a diuretic). It is taken by mouth.

Common side effects include dizziness, back pain, and upper respiratory tract infections. Serious side effects may include low blood pressure, kidney problems, allergic reactions, and electrolyte problems. Use in pregnancy and breastfeeding is not recommended. Losartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by decreasing the ability of the kidneys to absorb electrolytes. Interactions include with lithium, agents which increase potassium, and NSAIDs.

The combination was approved for medical use in the United States in 1995. It is available as a generic medication. A month supply in the United Kingdom costs the NHS about 1.50 £ per month as of 2019. In the United States the wholesale cost of this amount is about US$2.50. In 2017, it was the 67th most commonly prescribed medication in the United States, with more than eleven million prescriptions.