User:Mr. Ibrahem/Lymphedema

Lymphedema is localized swelling due to a compromised lymphatic system. Other symptoms may include discomfort, heaviness, joint stiffness, and skin thickening. Complications may include infection, deep vein thrombosis, and lymphangiosarcoma.

It most frequently occurs due to cancer and its treatment or parasitic infections (lymphatic filariasis), but may also be seen in a number of genetic disorders. Risk factors include obesity. The underlying mechanism involves a cycle of inflammation and fibrosis. Diagnosis is generally based on symptoms, after other potential causes are ruled out.

While there is no cure, treatment may improve outcomes. This commonly include compression therapy, good skin care, exercise, and manual lymphatic drainage (MLD), known together as combined decongestive therapy. Exercise may also be useful. Diuretics are not useful. Surgery is generally only used in those who are not improved with other measures.

Lymphedema affects approximately 200 million people worldwide. Women are more commonly affected than men. About 1 in 5 women who survive breast cancer and 40% of women with gynecologic cancer develop lymphedema. Genetic causes are much less common, occurring in about 1 in 100,000 people. The condition has been described throughout ancient history.