User:Mr. Ibrahem/Metolazone

Metolazone, sold under the brand name Zaroxolyn among others, is a medication used to treat fluid retention and high blood pressure. It may be used for fluid retention in heart failure or kidney disease. It is taken by mouth. Increased urine output may occur within an hour.

Common side effects include low potassium, low sodium, gout, high blood sugar, and abdominal bloating. Other side effects include high calcium, kidney problems, allergic reactions, and low blood pressure with standing. It may be used in pregnancy. It is a diuretic of the thiazide-like type. It works by increasing sodium and water loss in the urine.

Metolazone was patented in 1966 and approved for medical use in 1974. In the United States 100 tablets of 5 mg costs about 80 USD as of 2021. In Canada this amount costs about 40 CAD. Prescribing by brand is recommended as the bioavailability between different forms may vary.