User:Mr. Ibrahem/Mipomersen

Mipomersen, sold under the brand name Kynamro, is a medication used to treat homozygous familial hypercholesterolemia. Effects on overall risk of heart disease or death is unclear. Benefits in other types of high cholesterol is unknown. It is given by injection under the skin.

Common side effects include tiredness, nausea, headache, liver problems, fever, high blood pressure, and abdominal pain. Other side effects may include pain at the site of injection and angioedema. It is a short fragment of DNA, known as an antisense oligonucleotide, that blocks the production of apolipoprotein B.

Mipomersen was approved for medical use in the United States in 2013. In Europe it was denied approval in 2013 due to concerns of greater side effects than benefits. In the United States it costs about 407,000 USD per year.