User:Mr. Ibrahem/Nafarelin

Nafarelin, sold under the brand name Synarel among others, is a medication used to treat endometriosis and early puberty. It is also used for uterine fibroids, as part of in vitro fertilization (IVF), and as part of transgender hormone therapy. It is used as a nasal spray two to three times per day.

Common side effects in women include hot flushes, vaginal dryness, muscle pain, and sexual dysfunction. Common side effects in children include acne, mood changes, increased pubic hair, and vaginal bleeding. Other side effects may include allergic reactions, osteoporosis, and pituitary apoplexy. Use in pregnancy may harm the baby. It is a gonadotropin-releasing hormone agonist (GnRH agonist) and works by briefly increasing than decreasing the production of sex hormones by the gonads.

Nafarelin was approved for medical use in the United States in 1990. In the United Kingdom 60 doses of 200 mcg cost the NHS about £50 as of 2021. In the United States this amount costs about 2,800 USD. It is available in many countries globally. It is one of two GnRH analogues available as a nasal spray, the other being buserelin.