User:Mr. Ibrahem/Naldemedine

Naldemedine, sold under the brand name Symproic and Rizmoic, is a medication used to treat opioid-induced constipation in chronic non-cancer pain. It may be used when laxatives are not effective. It is taken by mouth.

Common side effects include abdominal pain, nausea, and diarrhea. Other side effects may include gastrointestinal perforation, allergic reactions, and opioid withdrawal. Safety in pregnancy is unclear. It is a peripherally acting μ-opioid receptor antagonist, which prevents opioids from binding to receptors in the gut. It generally dose not affect pain management.

Naldemedine was approved for medical use in the United States in 2017 and Europe in 2019. In the United States it costs about 330 USD per month as of 2021. In the United Kingdom this amount costs about £42.