User:Mr. Ibrahem/Naloxegol

Naloxegol, sold under the brand names Movantik and Moventig, is a medication used for opioid-induced constipation in people with long term non-cancer pain. It may be used when laxatives are not effective. It is taken by mouth. It generally dose not affect pain management.

Common side effects include abdominal pain, diarrhea, nausea, and headache. Other side effects may include opioid withdrawal and gastrointestinal perforation. Use in pregnancy has not shown harm; however such use has not been well studied. Chemically it is naloxone attached to polyethylene glycol (PEF). It is a peripherally acting μ-opioid receptor antagonist, which prevents opioids from binding to receptors in the gut.

Naloxegol was approved for medical use in the United States and Europe in 2014. In the United States it costs about 360 USD per month as of 2021. This amount in the United Kingdom costs the NHS about £55. As of 2015 it is no longer a controlled substance in the United States.