User:Mr. Ibrahem/Nelarabine

Nelarabine, sold under the brand names Arranon and Atriance, is a medication used to treat T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It is used when other treatments are not effective. It is given by gradual injection into a vein.

Common side effects include bone marrow suppression, sleepiness, headache, numbness, fever, swelling, and vomiting. Other side effects may include confusion, seizures, tumor lysis syndrome, and peripheral neuropathy. Use in pregnancy may harm the baby. It is an antimetabolite which replaces guanine and interferes with the making of new DNA.

Nelarabine was approved for medical use in the United States and Europe in 2005. In the United Kingdom six vials of 250 mg cost the NHS about £1,300 as of 2021. In the United States this amount costs about 4,600 USD. A generic version was approved in 2021 in the USA.