User:Mr. Ibrahem/Netupitant/palonosetron

Netupitant/palonosetron, sold under the brand name Akynzeo, is a combination medication for prevention of acute and delayed chemotherapy-induced nausea and vomiting. It is taken by mouth. It is used with dexamethasone.

Common side effects include headache, constipation, and tiredness. The dose does not need to be adjusted in those with mild to moderate liver or kidney problems. Use is not recommended in pregnancy. Netupitant is an NK1 receptor blocker and palonosetron is a 5-HT3 receptor blocker.

The combination was approved for medical use in the United States in 2014 and Europe in 2015. In the United Kingdom it costs the NHS about £70 a dose as of 2021. In the United States this amount costs about 680 USD.