User:Mr. Ibrahem/Nimesulide

Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) used for acute pain and painful periods. Use is recommended for less than 15 days. There is no evidence of benefit over other NSAIDs and due to side effects it is considered a second line treatment.

Side effects may include liver problems including those that result in the need for a liver transplant or death. Other side effects may include stomach problems. This issue occurs at a higher rate than other NSAIDs. It works primarily by blocking the enzyme COX-2 that makes prostaglandins.

Nimesulide has been approved for medical use in parts of Europe since 1985. It has never been approved in the United States, United Kingdom, Canada, Australia, New Zealand, or Japan due to safety concerns. Approval has been withdrawn in a number of countries including Spain, Ireland, and Finland.