User:Mr. Ibrahem/Olanzapine/samidorphan

Olanzapine/samidorphan (OLZ/SAM), sold under the brand name Lybalvi, is a combination medication used to treat schizophrenia and bipolar I disorder. It is taken by mouth. It contains olanzapine, an atypical antipsychotic, and samidorphan, an opioid antagonist.

Common side effects include weight gain, sleepiness, dry mouth, headache, tremor, and constipation. Other side effects may include an increased risk of death in people with dementia, opioid withdrawal, neuroleptic malignant syndrome, diabetes, tardive dyskinesia, low blood pressure with standing, and low white blood cells. It should not be used in people taking opioids. How olanzapine works is unclear. Samidorphan is present to try to reduce the weight gain from olanzapine.

The combination was approved for medical use in the United States in 2021. It is not available in the United Kingdom or Europe as of 2022. In the United States it costs about 1,500 USD per month as of 2022.