User:Mr. Ibrahem/Opicapone

Opicapone, sold under the brand name Ongentys, is a medication used with levodopa/carbidopa for Parkinson's disease. Specifically it is used for fluctuation in motor function before the next dose of levodopa. Benefits are similar to entacapone. It is taken by mouth.

Common side effects include difficulty controlling movement (dyskinesia). Other side effects may include constipation, low blood pressure, weight loss, and muscle breakdown. It works by enhancing the effects of levodopa and thus dopamine in the parts of the brain that control movement and coordination. It does this by blocks an enzyme involved in the breakdown of levodopa called catechol-O-methyltransferase (COMT).

Opicapone was approved for medical use in Europe in 2016 and the United States in 2020. In the United Kingdom a month of medication costs the NHS about £94 as of 2021. This amount in the United States costs about 630 USD.