User:Mr. Ibrahem/Palonosetron

Palonosetron, sold under the brand name Aloxi, is a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting. In delayed CINV there is tentative data suggesting it may be more effective than granisetron. It can be given by mouth or by injection into a vein.

Common side effects include QT prolongation, slow heart rate, headache, constipation, and weakness. Other side effects may include anaphylaxis and serotonin syndrome. Use in pregnancy appears to be safe, but such use has not been well studied. It is a 5-HT3 antagonist.

Palonosetron was approved for medical use in the United States in 2003 and Europe in 2005. It is on the World Health Organization's List of Essential Medicines as an alternative to ondansetron. It is available as a generic medication. In the United Kingdom it costs the NHS about £55 per dose as of 2021. This amount in the United States costs about 50 USD.