User:Mr. Ibrahem/Pegcetacoplan

Pegcetacoplan, sold under the brand name Empaveli among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH). Specifically it is used in adults who continue to have low red blood cells despite taking a medicine called a C5 inhibitor. It is given by gradual injection under the skin.

Common side effects include injection-site reactions, infections, diarrhea, abdominal pain, respiratory tract infection, viral infection, tiredness, and fever. Safety in pregnancy is unclear. Use requires people being vaccinated. It works by binding to and inhibiting complement protein C3.

Pegcetacoplan was approved for medical use in the United States and Europe in 2021. In the United Kingdom it costs the NHS about £24,800 for 4 weeks. In the United States this amount costs about 37,000 USD.