User:Mr. Ibrahem/Physostigmine

Physostigmine, sold under the brand name Antilirium among others, is a medication used to reverse anticholinergic effects and to treat hereditary ataxia including Friedreich ataxia. It is generally given by injection into a vein or muscle.

Common side effects include nausea, stomach pain, small pupils, sweating, and shortness of breath. Other side effects may include seizures, bronchospasm, cholinergic crisis, and asystole. Safety in pregnancy is unclear. It is a cholinesterase inhibitor.

Physostigmine was originally isolated from the Calabar bean. Its medical uses were discussed in the thesis of Thomas Richard Fraser at the University of Edinburgh in 1862. It was first manufactured in 1935 by Percy Lavon Julian. In the United States 2 mg costs about 80 USD as of 2021.