User:Mr. Ibrahem/Polymorphic eruption of pregnancy

Polymorphic eruption of pregnancy (PEP), also known as pruritic urticarial papules and plaques of pregnancy (PUPPP), is the most common specific skin condition of pregnancy. Symptoms include very itchy hives, small blisters, and widespread redness with a non-involved area around the belly button. It typically first appears within stretch marks before before spreading to the thighs and trunk; while the face, palms, and soles are not generally involved. Onset is typically in the later part of pregnancy or shortly after childbirth.

It most commonly affects women in their first pregnancy, those with larger bellies, and those carrying multiple pregnancies. While the underlying mechanism is unclear it may involve skin stretching. Diagnosis can often be based on symptoms. Generally, lab tests are normal, except for occasionally an increase in IgE.

Treatment is with corticosteroids. Generally these are applied to the skin such as betamethasone valerate 0.1%; though may occasionally be taken by mouth. Antihistamines, like cetirizine, may also be used. The condition resolves after delivery. It presents no long-term risks for either the mother or baby. It is unusual for it to reoccur.

Polymorphic eruption of pregnancy affects 1 in 120 to 300 pregnant women. In those with twins or triplets 3 to 17% are affected. Those affected may be twice as likely to be carrying a male baby. The condition was first described in 1979.