User:Mr. Ibrahem/Pralatrexate

Pralatrexate, sold under the brand name Folotyn, is a medication to treat peripheral T-cell lymphoma (PTCL). It is used when other treatments have failed. It is given by injection into a vein.

Common side effects include inflammation of the mouth, low platelets, nausea, and tiredness. Other side effects may include rash, tumor lysis syndrome, liver problems, and bone marrow suppression. Use in pregnancy may harm the baby. It is a dihydrofolate reductase inhibitor.

Pralatrexate was approved for medical use in the United States in 2009. Its approval was refused in Europe in 2012 due to insufficient evidence of benefit. In the United States 60 mg of medication costs about 18,000 USD.