User:Mr. Ibrahem/Progeria

Progeria is a genetic disorder in which symptoms resembling early aging occur in childhood. Symptoms generally become apparent between 9 to 24 months of age with decreased growth, small face, and hair loss. Those affected generally die between the age of 8 and 21 years old from heart disease.

The cause is usually a new mutation to a gene that produces the lamin A protein. After having one affected child, the chance of the next child being affected is as high as 3%. It is a type of progeroid syndromes. Diagnosis is based on symptoms and confirmed by genetic testing.

Treatment is mostly symptomatic. The medication lonafarnib was approved to treat progeria in 2020. About 1 in 6 million people born are affected. Males and females are affected equally frequently. Progeria was first described in 1886 by Jonathan Hutchinson and 1897 by Hastings Gilford.