User:Mr. Ibrahem/Progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is a degenerative disease of the brain that worsens over time. Symptoms including loss of balance, slowing of movement, difficulty moving the eyes, trouble swallowing, depression, and cognitive impairment. Complications may include pneumonia and falls.

The cause of the condition is uncertain, though appears to be partly genetic. There is typically no family history of the condition. The underlying mechanism involves a build-up of tau protein within the brain. It is a type of atypical parkinsonian syndrome. Diagnosis is based on symptoms and may be supported by medical imaging. Other conditions that may present similarly include Parkinson's, frontotemporal dementia, and Alzheimer's.

There is not specific treatment as of 2021, with care attempting to address symptoms. Medications such as levodopa and amantadine may temporarily improve symptoms in some people. Other measures may include use of a walker, special shoes, or special eye glasses. Life expectancy is about 7 years at diagnosis.

PSP affects about six people per 100,000. Onset of symptoms is typically in persons aged 45–75 years. Males and females are affected at similar rates. No association has been found with any particular race, location, or occupation. The condition was first clearly described in 1964 by Steele, Richardson, and Olszewski.