User:Mr. Ibrahem/Proton-pump inhibitors

Proton-pump inhibitors (PPIs) are a class of medications used for peptic ulcers, gastroesophageal reflux disease (GERD), and H. pylori infection. Common agents in this class include omeprazole, pantoprazole, rabeprazole, lansoprazole, esomeprazole, and dexlansoprazole. There is no clear evidence that one agent works better than another. They can be taken by mouth or given intravenously.

PPIs are generally safe. Common side effects may include headache, an upset stomach, and a change in taste. Serious side effects may include kidney failure, osteoporosis, low magnesium, and Clostridium difficile-associated diarrhea. While concerns have been raised about an interaction with clopidogrel, the significance if any is unclear.

They work by decreasing stomach acid production. They do so by blocking the H+/K+ ATPase. They are the strongest inhibitors of acid secretion available. This group decreases stomach acid more than H2-receptor antagonists.

The first medically useful PPI, omeprazole, was made in 1979. They are among the most widely used medications. One agent within the class, omeprazole, is on the World Health Organization's List of Essential Medicines. Some are available as generic medication and are relatively inexpensive.